In Vitro Fertilization (IVF)
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In Vitro Fertilization (IVF)

What is IVF?

"In vitro" refers to organic processes that take place outside the body - namely in the test tube. In IVF treatment, for example, the removed egg cell comes together with the man's sperm in the test tube. After successful fertilization outside the body, one or more fertilized egg cells are transferred (transferred) to the woman's uterus.

In vitro fertilization treatment (IVF) draws attention as a logical step for individuals whose infertility problem persists despite the traditional treatments initially applied.

The IVF method, which offers a fertility rate five times higher than the IUI method, is the most effective method today. IVF is also the most common fertility treatment and is very helpful for women who are older, have damaged fallopian tubes, and are experiencing male-factor infertility and the like.

Scientists Steptoe and Edwards first found success with IVF in 1978 with the birth of Louise Brown, now 38 years old. At that time, however, the doctors removed the egg cell in a spontaneous menstrual cycle. Today, on the other hand, women's ovaries are in most cases stimulated with the help of hormones. This means that several egg cells can mature and be removed at the same time.

What is the IVF method?

  • First, you need to meet with a reliable assisted reproductive therapist. You do not go to a non-specialist for another treatment, and do not go to a non-specialist for IVF. After you start by meeting with an expert, you will go through a number of different checks and interviews. This type of assistance produces much better results and helps both parties understand where they are.

  • After you get through this first assisted reproductive therapy acquaintance, you will start using drugs that regulate the natural menstrual cycle. Medication is vital as it ensures the high success rate of the two-stage program. Usually, you will both use daily injections that you can administer yourself. This type of treatment takes approximately two weeks.

  • Next, the healthcare team will make sure your egg supply is at the appropriate strength for the next stage of the process. This means the use of follicle stimulating hormone or FSH. This helps increase your ovaries' capacity to produce eggs and increases the chances of fertilization.

  • At this stage, you often go through a process analysis and an assessment of how things are progressing. This usually involves ultrasound scans and blood tests to make sure everything is okay. You also usually get an extra injection of hormones to speed up the process.

  • Your eggs are then collected during a quiet treatment session. This process does not take very long and is much less harmful or irritating than it currently appears. When the eggs are collected, they are prepared to be combined with the sperm of the partner or the donor in the laboratory. Once this is done, they are allowed to fertilize in their own private incubator.

  • Finally, the embryo is transplanted into the body. This transplant is performed using a catheter tube, making the procedure quick, painless, and often without sedative medication. 

Various factors will determine the number of eggs that will be retrieved. Therefore, there is no definite plan for this section. It totally depends on your situation.

Process Of Turkishdoc

For treatment planning and preliminary preparations, you need to contact us 2 months before the date you want to start the process.

Treatment begins with the menstrual period.

With the use of egg-developing needles in the expectant mother, the treatment process begins.

Needle usage continues for about 12-15 days.

After the use of the needles is over, the expectant mother should come to our center to collect the eggs and the father-to-be should come to our center to give a sperm sample.

According to the preference of the expectant mother, she can return to her home 3-4 hours after the egg procedure or stay in Cyprus until the transfer day. The father-to-be does not need to come to the clinic on the transfer day.

During this time, the expectant mother must return to our center for the transfer process 3-5 days after the egg collection process. The expectant mother can return 4 hours after the transfer process.

12 days after the transfer, the expectant mother can learn the result by taking a blood pregnancy test in the city where she lives. The expectant mother continues to take some hormone medications after the transfer until the baby's heartbeat is heard.

Who is IVF suitable for?

On the one hand, IVF is an option for couples where the woman has a blocked fallopian tube, endometriosis or antibodies against the partner's sperm cells. However, it is also suitable for couples where the man's sperm cells are so bad that insemination has already been unsuccessful.

IVF: chance of success

The fact that IVF treatment today has significantly better success rates than in the past is mainly due to the removal of several egg cells or ovarian stimulation with gondotropins. The success rate of ivf can be increased if the doctor transfers several embryos at the same time. But then there is the possibility of a multiple pregnancy.

However, the pregnancy rate does not correspond to the birth rate, which is somewhat worse due to miscarriages - it is around 23 percent per embryo transfer. The proportion of multiples is less than 20 percent.

In individual cases, the type of fertility disorder and age have a decisive influence on the success of in vitro fertilization. For example, the older the woman, the lower the pregnancy and birth rate after embryo transfer.

What complications do you have to expect?

If the first hurdle, fertilization of the egg and sperm cells in the laboratory, is successful, the next is implantation. About 14 days after the transfer of the fertilized eggs, a pregnancy test shows whether one or more embryos have implanted themselves in the uterus. In addition, with IVF, the risk of an ectopic pregnancy is slightly increased.

Pros and cons of IVF

In vitro fertilization only works with hormone treatment, and this can be mentally and physically stressful for the woman. There is also a risk of ovarian hyperstimulation syndrome. It's potentially life-threatening, but fortunately very rare. 

If more than one embryo is implanted after in vitro fertilization, you can expect to have twins or triplets. A multiple pregnancy is generally associated with an increased risk of premature birth and miscarriage.

Although IVF has been around for a long time, its impact on children's development is still being researched. Two studies were recently able to show that the culture medium used, in which the fertilized egg cells grow, influences the development of the children. What exactly leads to this cannot be said, since the companies keep the exact composition of their nutrient solutions secret. However, researchers have been demanding disclosure of the ingredients for some time.

What happens to the remaining embryos?

During IVF treatment, more fertilized egg cells are often produced in the laboratory than are later placed in the uterus. The surplus embryos are frozen in liquid nitrogen with the consent of both parents. A prerequisite for this cryopreservation is, in addition to the consent of both partners, that the embryos are still in the pronuclear stage.

At this point in time, the genome of the mother and father is still separate in the egg cell and has not yet arranged itself into an independent set of chromosomes. Even unfertilized egg cells can be cryopreserved for later treatment.

The advantage: If the woman does not become pregnant in the first treatment cycle, she does not need to undergo any further hormone stimulation for the second transfer. However, not all women benefit from this, as not enough fertilizable egg cells for several transfers can be obtained with every stimulation.

What can we do if in vitro fertilization didn't work out?

The couple discusses with the attending physicians whether another method of artificial insemination makes sense after an unsuccessful IVF. If the problem was already with the fertilization of the egg cell, this could be due to reduced sperm quality.

In this case, Intracytoplasmic sperm injection (ICSI), an intracytoplasmic sperm injection, may be more successful. In ICSI, a single sperm is injected directly into the egg using a very fine needle. Independent fertilization is removed from the egg and sperm cell. In order for an ICSI treatment to be carried out, the reduced sperm quality must be proven by two spermiograms in the case of those with statutory health insurance.


The expectant mother will return 3-4 hours after the egg collection process or remain in Cyprus until the transfer day.

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