What are the Causes If Pregnancy Does Not Occur After Embryo Transfer?

Pregnancy may not happen after embryo transfer (ET) due to various reasons. The most common reasons include:

-        Chromosomal abnormalities: This is the most common cause of failed implantation after ET. Even embryos that look healthy in the laboratory may have genetic problems that prevent them from attaching to the uterus or developing  properly.

-        The uterine lining may not be strong enough: The uterine lining refers to the layer of tissue in the uterus where the embryo attaches. The embryo may not be able to attach to the uterine lining if it is not strong or healthy enough.

-        Inflammation or infection of the uterus: It can be difficult for the embryo to attach if the uterus becomes inflamed or infected.

-        Autoimmune diseases: In some situations, these diseases can stop the embryo from attaching.

-        Endometriosis: The growth of tissue that lines the uterus outside the uterus is a condition called endometriosis. This growth can sometimes prevent a fertilized egg from implanting successfully.

-        Age: Age plays a significant role in the chances of pregnancy after ET. Women over 40 are less likely to get pregnant compared to younger women.

If pregnancy doesn’t occur after embryo transfer, the doctor will investigate the cause and explore potential treatments with the couple. The couple may need more tests or medical treatment before another embryo transfer is attempted.

What should be done if pregnancy does not occur  after embryo transfer?

If pregnancy does not occur after embryo transfer, it is important to talk to your doctor to understand why. There are many factors that can affect the success of an embryo transfer, and your doctor will be able to help you identify the causes in your case.

Once you understand the reasons why you have not become pregnant, you can discuss your options for the next steps with your doctor. These may include:

Trying to transfer the embryos again: Another embryo transfer may be successful if the embryos are of good quality and the uterine lining is healthy.

Chromosomal abnormality testing If the embryos were not of good quality or the lining of the womb was not healthy, your doctor may recommend chromosome testing. This can be a way of identifying any genetic problems that may have an impact on your fertility.


Treatment for underlying health conditions: If you have any underlying health conditions that may be affecting your fertility, your doctor may recommend treatment for these conditions.

It is important to remember that every case of infertility is different. There is no single answer to the question of what to do if pregnancy does not occur after embryo transfer. The best course of action will depend on your individual circumstances.

When is it appropriate to try again if pregnancy does not occur after embryo transfer?

Following an unsuccessful embryo transfer, the appropriate time to try again depends on several factors, such as:

Age: Younger women are more likely to have successful embryo transfers later.

The quality of the embryos: An embryo with a high grade has a greater chance of implantation than one with a low or fair grade.


The woman's medical history: Women with underlying health conditions such as endometriosis or PCOS may need to wait longer before trying again.

The woman's emotional state: It is crucial to be emotionally prepared before attempting another embryo transfer after a failed attempt.

In general, doctors recommend waiting at least two to three months after a failed embryo transfer before trying again. This gives the woman's body time to recover and her hormones to normalize. Moreover, this gives the couple some time to think about whether they want to try again after the failed transfer.

If the woman is under 35 and the embryos were of good quality, she may be able to try again sooner, within 1-2 months. To make sure that it is the best option for you, it is important to discuss this with your doctor.

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